Effect of Xenon on the Phosphorylation of Glycogen Synthase Kinase 3β and Antioxidant Enzymes in Rat Brain

Relevance. The increase in the number of severe brain injuries due to stroke and traumatic injury determines need study develop effective strategies for neuroprotection. article highlights new mechanisms neuroprotective action inhalation anesthetic xenon based on data our own experimental studies. Aim study. To assess effect anesthesia with at a concentration 0.5 MAC (minimum alveolar concentration) phosphorylation glycogen synthase kinase 3β (GSK-3β) content antioxidant defense enzymes rat brain. Material methods. GSK-3β enzyme comparison lithium chloride, as well heme oxygenase, catalase, Mn-superoxide dismutase homogenates was studied by immunoblotting. Results. use MAA causes an almost twofold phosphorylated form control (p<0.05) significantly increases pool enzymes: oxygenase 50% (p <0.05) 60% (p<0.05). Conclusion. conducted revealed molecular xenon. involved protection from oxidative distress found. obtained indicate prospects using require further research this direction. 50 vol.% (0.5 MAA) 30 minutes does not affect synthase-3β enzyme, same time causing its form, is accompanied significant slight catalase homogenates. Thus, results suggest that one possible synthase-3β, which prevents opening mitochondrial pore, inhibiting death mitochondria-mediated apoptosis neurons increasing level them.